CBD and Drug Interactions

CBD Oil use is on the rise! It’s safe, non-psychoactive, non-addictive, and has little to no negative side effects. The benefits of CBD are being explored and experienced every day by consumers who are looking to better their overall health and wellness with natural alternatives. While CBD can be used as a natural alternative to some medicines, it is so important to keep in mind that your body may still need some type of medication for it to stay balanced and healthy, whether it is a beta blocker, antidepressant, antipsychotic, steroids, antiviral, etc.

If you or someone you know is dependent on a medication and would like to use CBD as well, it is important to take certain precautions. Also, always consult with your doctor beforehand.

Can CBD interact with medications? The answer is yes. CBD, when ingested, can interact with specific types of medications.

When you ingest CBD, your liver metabolizes the oil into smaller compounds; while this is a normal process, metabolizing CBD specifically can inhibit or reduce the metabolism of other medications. This happens as an effect of inhibiting the cytochrome P-450 enzyme system in the body.

What is the Cytochrome P450 Enzyme System?

The cytochrome P450 enzyme system is made up of many CYP enzymes that are found in the liver. They help the liver metabolize toxic compounds often found in prescription medications. These enzymes assist in processing and eliminating any toxins. When something inhibits the cytochrome P450 system, the time it takes to process medication slows, which can potentially cause a build-up of toxins if proper dosing adjustment are not practiced.

Quick Tip
Did you know that grapefruit, turmeric, echinacea, and caffeine all have the same effect on the CYP enzymes as CBD? If a medication you are taking suggests to not eat grapefruit while you are taking it, you will want to use the same caution with CBD as the drug interaction may be similar. Drug interactions like these are not prevalent, but your physician may need to adjust or monitor your medication dosage to be sure it does cause a more severe interaction.

Is there a way to avoid drug interactions while still using CBD?
There are so many ways to use CBD. Since potential drug interactions can happen when ingesting CBD oil, topical use is always an alternative. Using CBD topically will not cause a drug interaction as the cannabinoids are absorbed through the skin and into the muscles, joints, and bloodstream.

CBD offers so many benefits, but it is important to make sure that you use it safely and under the direction of your doctor, especially if you are taking other medications. For some people, CBD may be able to replace some or all medications, but for others, prescription medications may still be a part of everyday life. If you are taking any medications, make sure to discuss any questions or concerns with your doctor before using CBD.

Resources:
CBD Oil Review | Drugs that May Interact with CBD Oil | 2018
https://cbdoilreview.org/cbd-cannabidiol/cbd-p-450-enzyme/

Project CBD | CBD-Drug Interactions: Role of Cytochrome P450 | 2015
https://www.projectcbd.org/science/cannabis-pharmacology/cbd-drug-interactions-role-cytochrome-p450

Leafly | How Does Cannabis Interact With Other Drugs?
https://www.leafly.com/news/health/cannabis-cannabinoids-drug-interactions

Hemp Lucid | CBD – Drug Interactions – What you need to know
https://www.hemplucid.com/blogs/health/cbd-drug-interactions/

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